National Institute of Mental Health 1K23MH139900-01A1

An Artificial Intelligence Foundation Model for Functional Neuroimaging: Personalized Prediction, Treatment Stratification, and Biotype Discovery in Major Depressive Disorder

Development of AI foundation models for neuroimaging to personalize treatment and predict outcomes in major depressive disorder, including clinical trial evaluation.

Description

This project aims to leverage foundation models—transformer-based AI architectures pretrained on large datasets like UK Biobank—to develop neuroimaging tools for prognostication, treatment stratification, and biotype discovery in major depressive disorder (MDD). The research involves fine-tuning models on pooled fMRI data to decode depression severity, predict antidepressant response, and identify neural circuits associated with treatment response. The project includes a pilot clinical trial to evaluate MRI-based treatment prediction models.

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