Award
National Institute on Deafness and Other Communication Disorders 5R01DC020842-05
Understanding the neuronal mechanisms of closed-loop olfaction
Recipient
Cold Spring Harbor Laboratory
Award Amount
$556,658.00
Ceiling
$556,658.00
Awarded
July 20, 2026
Identifier
5R01DC020842-05
This NIH-funded project investigates how mice use sensorimotor predictions to guide olfactory perception and neural coding in a closed-loop system, employing novel behavioral tasks and advanced genetic and recording techniques.
Description
The project aims to test the hypothesis that in closed-loop olfaction, mice generate olfacto-motor predictions about the sensory consequences of their actions, which further guide odor sampling movements. It involves developing a novel odor localization task (Smellocator), analyzing cortical responses to sensorimotor perturbations, and exploring the roles of specific cell types in olfactory cortex in sensorimotor prediction and adaptation.