Award
National Cancer Institute 5R01CA256840-05
Linear energy transfer (LET) dependencies for understanding pancreatic tumor control and relevant molecular endpoints in support of RBE-based heavy-ion radiotherapy
Recipient
Columbia University Health Sciences
Award Amount
$506,127.00
Ceiling
$506,127.00
Awarded
December 12, 2024
Identifier
5R01CA256840-05
A research project funded by the National Cancer Institute to study the effects of heavy-ion radiotherapy on pancreatic cancer, focusing on LET dependencies and ferroptosis induction to enhance treatment efficacy.
Description
This project investigates the LET dependencies of heavy-ion radiotherapy effects on pancreatic ductal adenocarcinoma (PDA) using mouse models and high-LET charged particle beams. It aims to optimize heavy-ion therapy by quantifying endpoints with and without ferroptosis induction, potentially improving treatment outcomes for pancreatic cancer.