Award
National Institute on Aging 5R01AG015819-21
Risk Factors, Pathology, and Clinical Expressions of AD
Recipient
Rush University Medical Center, Chicago, IL
Award Amount
$2,868,751.00
Ceiling
$2,868,751.00
Awarded
May 24, 2024
Identifier
5R01AG015819-21
NIH funded research project to identify molecular targets and mechanisms in Alzheimer's disease using multi-omic data from human brain samples, aiming to discover therapeutic targets.
Description
This project aims to identify proteins, isoforms, proteolytic fragments, and PTMs associated with Alzheimer's disease (AD) and related pathologies using multi-omic data from 750 human brains. The research focuses on regions such as the hippocampus and entorhinal cortex to discover high-value therapeutic targets. The study involves generating bulk and single-cell RNA sequencing and proteomics data, identifying molecular systems driving AD traits, and performing top-down proteomics to analyze splice isoforms and PTMs.