Award
National Institute on Alcohol Abuse and Alcoholism 5U01AA029969-05
5/11 Microglial MyD88 in Mouse Models of Excessive Alcohol Intake
Recipient
Duke University, Durham, NC, USA
Award Amount
$393,579.00
Ceiling
$393,579.00
Awarded
February 06, 2026
Identifier
5U01AA029969-05
Research project funded by the National Institute on Alcohol Abuse and Alcoholism studying the role of microglial MyD88 in regulating brain cells and structures related to alcohol use disorder, aiming to understand mechanisms behind excessive alcohol intake and develop novel treatments.
Description
This project investigates microglial regulation of neuronal plasticity mechanisms involved in alcohol use disorder, potentially leading to novel treatments. The research aims to determine if microglial-MyD88 directly or indirectly regulates parvalbumin positive GABAergic interneurons (PVIs) and perineuronal nets (PNNs) in response to alcohol and how these contribute to excessive alcohol consumption.