Award
NIH Reporter #4DP1NS142487-03
Targeted Degradation of Extracellular Proteins to Enhance Brain Plasticity
Recipient
SALK INSTITUTE FOR BIOLOGICAL STUDIES
Award Amount
$3,990,000.00
Ceiling
$3,990,000.00
Awarded
September 04, 2026
Identifier
4DP1NS142487-03
Award for developing a system to enhance brain plasticity by targeted degradation of extracellular proteins, with applications in neurological disorders.
Description
The project aims to develop a genetically encoded system for Targeted Degradation of Extracellular Proteins (TDEP) to enhance brain plasticity by transiently increasing neuronal plasticity through degrading specific extracellular proteins that inhibit synaptic remodeling, using nanobodies coupled with degradation sequences. It will generate an atlas of extracellular proteins and their cellular sources to promote brain health and repair.