Award
National Institute of General Medical Sciences 5R35GM148352-04
Mechanisms of Translation Control in Humans
Recipient
University of California Berkeley
Award Amount
$608,321.00
Ceiling
$608,321.00
Awarded
January 30, 2026
Identifier
5R35GM148352-04
Research project focused on understanding translation control mechanisms in humans to aid therapeutic development, including drug targeting and immunotherapy.
Description
This project aims to reveal fundamental aspects of translation control in humans, with long-term applications in human therapeutics, including targeting “undruggable proteins” and cellular immunotherapy. The project explores regulation of translation initiation and elongation, focusing on the role of eIF3 and its interactions with structured RNA elements, as well as mechanisms of translation frameshifting and the development of small molecule modulators.