Award
National Institute of Neurological Disorders and Stroke 5R01NS041280-25
Resilience, Dysregulation, and Rescue of Basal Ganglia Indirect Pathway Function in Progressive Parkinsonism
Recipient
Northwestern University, Chicago, IL
Award Amount
$565,162.00
Ceiling
$565,162.00
Awarded
April 07, 2026
Identifier
5R01NS041280-25
Research project funded by NINDS to study Parkinson's disease mechanisms and potential therapies using a genetic mouse model.
Description
This project studies the progression of brain circuit and motor dysfunction in a genetic mouse model of Parkinson's disease to understand the resilience and dysregulation of brain function due to degeneration of substantia nigra dopaminergic neurons, and explores correction of abnormal circuit activity to rescue movement or prevent neurodegeneration.