Award
National Cancer Institute 5U01CA296432-02
Characterizing genetic risk of cancer across diverse populations through multi-ancestry epigenome profiling and chromatin QTL discovery
Recipient
Dana-Farber Cancer Institute
Award Amount
$710,144.00
Ceiling
$710,144.00
Awarded
May 12, 2026
Identifier
5U01CA296432-02
A research project funded by the National Cancer Institute to study genetic risk factors for cancer in diverse populations, focusing on multi-ancestry epigenome profiling and chromatin QTL discovery to improve understanding and personalized medicine.
Description
This project will enable functional characterization of cancer-causing genetic variants that are common in populations of non-European ancestry but poorly represented in existing chromatin QTL datasets. It aims to benefit populations that have been understudied in cancer genetics research by identifying chromatin QTLs (cQTLs) associated with cancer risk, improving polygenic risk scores, and discovering cancer-associated cQTLs from circulating chromatin in plasma samples.