Award
National Heart, Lung, and Blood Institute 5R01HL161122-04
Regulation of compartmentalized cAMP signaling by mitochondria-associated spaces in adult ventricular myocytes
Recipient
University of Nevada Reno
Award Amount
$462,014.00
Ceiling
$462,014.00
Awarded
July 04, 2025
Identifier
5R01HL161122-04
NIH grant awarded to University of Nevada Reno to study how mitochondria-associated spaces regulate compartmentalized cAMP signaling in heart cells, aiming to understand mechanisms and develop therapies for cardiac diseases.
Description
This NIH grant project aims to explore the hypothesis that tight spaces associated with mitochondria regulate cAMP compartmentation in adult ventricular myocytes, focusing on proteins GRP75 and MLP. The study seeks to elucidate mechanisms facilitating cAMP compartmentation and develop therapeutic strategies for cardiac diseases.