National Institutes of Health 5R35GM136280-07

Molecular Mechanisms of Cell Cycle Control

This NIH-funded project investigates molecular mechanisms controlling cell cycle progression and adaptation to stress, aiming to identify strategies to inhibit cancer cell proliferation.

Description

The project aims to understand the pathways that control the cell cycle to identify strategies for inhibiting the proliferation of cancer cells. It focuses on how multisite phosphorylation regulates protein function to drive cell cycle progression and the importance of cell cycle regulation for cells to adapt and survive in stressful environments. The research uses molecular and systems level approaches in budding yeast and human cells to uncover conserved mechanisms controlling proliferation, potentially offering targets for cancer intervention.

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