Award
National Institute on Aging 5R01AG074932-05
Discovery and manipulation of transcription factors to restore long term stem cell repopulation in aged bone-marrow
Recipient
Brigham and Women's Hospital
Award Amount
$697,062.00
Ceiling
$697,062.00
Awarded
May 14, 2026
Identifier
5R01AG074932-05
This NIH grant supports research to identify and manipulate transcription factors to rejuvenate aged hematopoietic stem cells, aiming to restore their long-term repopulation ability and improve systemic health in aging mice.
Description
The project aims to understand and reverse hematopoietic stem cell (HSC) aging through cellular reprogramming. It involves profiling molecular signatures of aging in HSCs at single-cell resolution, identifying transcription factors (TFs) involved in aging and self-renewal, and screening TFs for their potential to restore HSC function and systemic health in aging mice. The research will characterize novel TFs, evaluate their effects in vitro and in vivo, and explore their potential as therapeutic targets for aging-related diseases.