Florida Department of Veterans' Affairs 5I01BX003303-08

Slowing proteotoxic neurodegeneration by boosting mitochondrial bioenergetics and recruiting a novel class of chaperones

This award supports research to explore metabolic and proteostasis pathways in human neurons to develop therapies for neurodegenerative diseases such as Huntington's and Parkinson's. It uses yeast, human, and mouse models to study NAD+ biosynthesis enzymes with chaperone functions, aiming to protect neurons and extend health-span, particularly benefiting veterans.

Description

The project aims to understand the interaction between metabolic pathways and proteostasis in human neurons to develop therapeutic strategies for neurodegenerative diseases. The research involves yeast models, human iPSC-derived neurons, and mouse models. The focus is on NAD+ biosynthesis enzymes with moonlighting chaperone functions. The project is funded by VA and aims to benefit veterans and the general population.

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