Award
Eunice Kennedy Shriver National Institute of Child Health and Human Development 1R56HD116739-01A1
Understanding endometrial tissue field defects in obesity-related endometrial hyperplasia
Recipient
Henry Ford Health + Michigan State University Health Sciences, East Lansing, MI, United States
Award Amount
$1,394,304.00
Ceiling
$1,394,304.00
Awarded
August 29, 2025
Identifier
1R56HD116739-01A1
NIH grant awarded to study mechanisms by which obesity influences endometrial hyperplasia development, using animal models and molecular techniques to identify biomarkers and prevention strategies.
Description
This NIH grant supports research to determine the mechanism of how obesity and other risk factors alter the uterine endometrial microenvironment to promote conditions favorable for endometrial hyperplasia development and progression. The project uses genetically engineered mouse models, high-fat diet-induced obesity models, histopathological assessments, adoptive bone marrow transfers, and ‘omics’ approaches to understand hyperplasia development and progression, aiming to identify early biomarkers for risk prediction and prevention strategies.