Award
National Institute of Neurological Disorders and Stroke 5R00NS110978-05
Cerebellar Outputs Through an Unconventional Nucleus
Recipient
Pennsylvania State University Hershey Medical Center
Award Amount
$220,746.00
Ceiling
$220,746.00
Awarded
March 26, 2025
Identifier
5R00NS110978-05
Research project funded by NINDS to study cerebellar output pathways and their role in fear extinction and PTSD, with potential for targeted interventions for cerebellar dysfunction disorders.
Description
The project aims to characterize cerebellar inputs to the parabrachial nucleus and identify novel cerebellar output targets, focusing on projections to the amygdala. It investigates the role of an additional output pathway through the parabrachial nucleus that receives direct Purkinje cell input and projects to the forebrain, including regions involved in fear extinction and PTSD.