Award
NIH Reporter #5R01DK114457-07
TWEAK/TNFSF12 and LIGHT/TNFSF14 interactions in allergic esophagitis remodeling
Recipient
University of California, San Diego
Award Amount
$696,727.00
Ceiling
$696,727.00
Awarded
May 29, 2026
Identifier
5R01DK114457-07
NIH grant awarded to University of California, San Diego for research on allergic esophagitis remodeling focusing on TWEAK and LIGHT protein interactions and their role in esophageal structural changes.
Description
This NIH grant supports research on esophageal remodeling related to allergic diseases, focusing on cytokine interactions and potential therapeutic targets. The project aims to define proteins that contribute to esophagus remodeling, fibrosis, and smooth muscle dysmotility, focusing on extracellular proteins LIGHT/TNFSF14 and TWEAK/TNFSF12. The study will utilize primary human esophageal cells, tissues, biopsies from normal and EoE patients, and murine models of allergic esophagitis, including gene-deficient mice. Pre-clinical therapeutic blocking strategies will explore the interactions of TWEAK and LIGHT with IL-13 and IFNγ, potentially identifying new targets for therapeutic intervention.