Award
National Institute on Drug Abuse 1K99DA066035-01
Investigating opioid-induced dopamine rhythms and their role in respiratory suppression
Recipient
Stanford University, Department of Psychiatry
Award Amount
$158,534.00
Ceiling
$158,534.00
Awarded
May 14, 2026
Identifier
1K99DA066035-01
A NIH-funded research project at Stanford University studying how opioid-induced dopamine rhythms affect respiratory suppression, aiming to find new therapeutic targets for opioid overdose.
Description
This project investigates opioid-induced rhythmic dopamine release and its role in respiratory suppression, particularly focusing on opioid-induced respiratory depression (OIRD) caused by fentanyl. The research aims to understand the origin, function, and molecular mechanisms of dopamine rhythms in the ventral tegmental area (VTA) and their potential as a safety signal to maintain breathing under hypoxic stress. Techniques include optogenetics, patch clamp electrophysiology, and single-cell RNA sequencing.