National Institute of General Medical Sciences 3R01GM112715-09S1

Developmental disruption of brain tissue oxygen regulation and deficiency of learning after neonatal anesthesia exposure

This award provides supplemental funding to purchase an advanced electrophysiological recording system to improve research on the effects of general anesthesia on brain neuronal activity and oxygen regulation in neonatal subjects.

Description

We are seeking supplemental funding to purchase an advanced electrophysiological recording system to study the effects of general anesthesia on neuronal activity in the brain. This project studies the effects of general anesthesia on neuronal activity and oxygen levels in the cerebral cortex, requiring continuous recording via chronically implanted electrodes. Our existing system is old and increasingly unreliable, and moreover, it is insufficient for our experiments, especially when multiple kits are born simultaneously. A new system will allow us to monitor more animals simultaneously and offer improved design and signal quality. The updated system will reduce experimental time, ensure cleaner data, and enable better comparisons between oxygen levels and electrophysiological signals. Acquiring the new Neuralynx system will enhance our recording capabilities, benefiting our current and future research. We seek additional funding to procure this system, confident in its substantial contributions to our work.

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