Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 5R01AR081904-04
Targeting TGFb In Osteogenesis Imperfecta
Recipient
Baylor College of Medicine
Award Amount
$594,558.00
Ceiling
$594,558.00
Awarded
July 08, 2026
Identifier
5R01AR081904-04
NIH research grant awarded to Baylor College of Medicine to develop and assess anti-TGF therapies for Osteogenesis Imperfecta, focusing on bone strength and fracture healing.
Description
This project aims to study the effectiveness of bone-targeted therapies and mechanisms for increasing bone strength in Osteogenesis Imperfecta (OI), focusing on the role of Transforming Growth Factor beta (TGF). The research involves developing anti-TGF antibodies, assessing their efficacy across different severities of OI, and understanding their impact on fracture healing and bone remodeling.