Award
University of Massachusetts 5R24OD036199-03
Novel Humanized Mouse Models For Engraftment of Tissue-Specific Human Macrophage Population
Recipient
UNIV OF MASSACHUSETTS MED SCH WORCESTER
Award Amount
$846,167.00
Ceiling
$846,167.00
Awarded
July 15, 2026
Identifier
5R24OD036199-03
Award for developing humanized mouse models to study tissue-specific human macrophages and their role in various diseases including Alzheimer's, multiple sclerosis, and HIV.
Description
This project aims to develop humanized mouse models to study tissue resident macrophages and their role in diseases such as Alzheimer’s Disease, multiple sclerosis, and HIV infection. The project involves genetic modification of NSG mice, engraftment with human HSCs, and evaluation of macrophage development and disease modeling.