Award
National Institute of Allergy and Infectious Diseases 4R01AI170952-04
Molecular and functional investigation of the role of HLA-F in immune regulation
Recipient
University of Chicago, Chicago, IL, United States
Award Amount
$1,338,336.00
Ceiling
$1,338,336.00
Awarded
May 30, 2025
Identifier
4R01AI170952-04
This NIH grant supports research on the molecular and functional roles of HLA-F in immune regulation, focusing on its structural conformers, receptor interactions, and regulatory mechanisms.
Description
The project aims to understand the molecular and functional mechanisms of HLA-F, including its conformational states, receptor interactions, and regulatory factors. HLA-F is a nonclassical MHC class I molecule involved in cancer, HIV, autoimmunity, and reproduction.