Award
National Institute of General Medical Sciences 5R35GM158169-02
Virus breathing and assembly–disassembly transitions in host entry
Recipient
PENNSYLVANIA STATE UNIVERSITY, THE, UNIVERSITY PARK, PA, UNITED STATES
Award Amount
$387,783.00
Ceiling
$387,783.00
Awarded
May 11, 2026
Identifier
5R35GM158169-02
Research project funded by NIGMS to study virus disassembly and entry into host cells using advanced structural and biochemical methods, aiming to improve understanding of viral infection and support therapeutic discovery.
Description
The project aims to determine the steps for how intact virus particles disassemble upon interactions with host cell receptors to release the viral genome inside the human host cell. It involves monitoring virus dynamics in multiple icosahedral model viruses through integrative structural mass spectrometry, cryo-electron microscopy, biophysical and RNA chemistry approaches. The research focuses on understanding virus entry mechanisms and aiding therapeutic development.