Award
National Institute of Allergy and Infectious Diseases 5K08AI168487-04
Immunometabolic signatures of BCG-induced neonatal trained immunity
Recipient
Beth Israel Deaconess Medical Center, Boston, MA, United States
Award Amount
$175,572.00
Ceiling
$175,572.00
Awarded
July 15, 2026
Identifier
5K08AI168487-04
A 5-year NIH-funded research project studying the immunometabolic mechanisms of BCG vaccine-induced trained immunity in newborns to inform early life vaccine development.
Description
This proposal presents a 5-year research career development program focused on the study of BCG vaccine and the mechanisms of innate immune memory, known as trained immunity, underlying its pathogen-agnostic protective health effects in early life. The candidate aims to characterize immunometabolic mechanisms of BCG-induced trained immunity in newborns, investigating immunometabolic signatures in human newborn monocytes, validating pathways in vivo, and exploring age-specific metabolic pathways in vitro. This research will provide insights into cellular and molecular mechanisms of BCG-induced trained immunity, informing future early life vaccine development.