Award
National Institute of Diabetes and Digestive and Kidney Diseases 2R01DK128861-05A1
Mechanisms of Hepatocyte Polarization and Apical Tube Formation
Recipient
University of Pennsylvania
Award Amount
$697,454.00
Ceiling
$697,454.00
Awarded
May 05, 2026
Identifier
2R01DK128861-05A1
Research project awarded to University of Pennsylvania to study mechanisms of hepatocyte polarization and bile canaliculus formation, aiming to understand liver architecture and disease.
Description
The project focuses on understanding the mechanisms governing hepatic polarity and bile canaliculus (BC) development, which are critical to liver architecture and function. Defects in these processes are linked to liver diseases such as cholestasis and hepatocarcinoma. Using models including rat hepatocytes, mouse, and human HepG2 cells, the study aims to uncover fundamental mechanisms of BC formation and elongation, with implications for liver disease insights.