Award
National Cancer Institute 5F31CA284547-04
Targeting fibrosis to change cancer outcomes
Recipient
University of Cincinnati, Department of Pediatrics
Award Amount
$49,524.00
Ceiling
$49,524.00
Awarded
July 24, 2025
Identifier
5F31CA284547-04
This award funds research to understand and target fibrosis-related mechanisms that increase lung cancer risk in Scleroderma patients, focusing on senescent myofibroblasts and LIGHT signaling pathways to develop novel therapeutics.
Description
Research project aimed at targeting pathogenic cells responsible for fibrosis to change cancer outcomes, specifically focusing on Cancerous Scleroderma (CSc) and lung cancer risk in patients with Scleroderma (SSc). The project investigates the role of senescent myofibroblasts and LIGHT signaling in driving fibrosis and cancer, with goals to identify molecular pathways and translate findings to human tissue for potential therapeutic development.