Award
NIH Reporter #2R01DK130227-05A1
Metaorganismal Endocrinology in Cardiometabolic Disease
Recipient
Cleveland Clinic Lerner College of Medicine
Award Amount
$725,937.00
Ceiling
$725,937.00
Awarded
August 03, 2026
Identifier
2R01DK130227-05A1
NIH grant awarded to Cleveland Clinic Lerner College of Medicine to study the role of gut microbes in metabolic and circadian regulation related to cardiometabolic diseases, with a focus on microbial metabolism of nutrients and its impact on disease susceptibility and circadian rhythms.
Description
This project explores a pathway where nutrients in high-fat foods are metabolized by gut microbes to generate trimethylamine (TMA), which is further processed by the host enzyme FMO3 to produce TMAO. Pharmacologic inhibition of the microbial enzyme CutC/D protects mice from high-fat diet-related metabolic disturbances and reorganizes host circadian control of lipid metabolism, olfactory perception, and gut microbial ecology. The research aims to uncover a diet-microbe-derived zeitgeber, potentially leading to novel therapeutic strategies for circadian-related diseases.