Award
National Institute on Drug Abuse 5R21DA059363-03
Nucleophile-Fragment Screening for Site-Specific Covalent Ligand Discovery in Opioid Receptor Signaling
Recipient
Florida Atlantic University, Boca Raton, FL
Award Amount
$190,625.00
Ceiling
$190,625.00
Awarded
March 19, 2025
Identifier
5R21DA059363-03
This award funds research to discover covalent ligands targeting oxidized cysteines in opioid receptor signaling, potentially leading to new treatments for addiction.
Description
The project develops and applies a chemoproteomics approach to identify S-sulfenated cysteine ligandability in mu opioid receptor signaling, aiming to discover small molecules for treating addiction and substance use disorders.