Award
National Institute of Allergy and Infectious Diseases 5R01AI134989-08
Type 2 Inflammation and Remodeling Elicited Through an LTE4/OXGR1-dependent pathway
Recipient
Brigham and Women's Hospital, Boston, MA, United States
Award Amount
$712,176.00
Ceiling
$712,176.00
Awarded
December 30, 2025
Identifier
5R01AI134989-08
Research grant to study airway inflammation and remodeling via tuft cells and LTE4/OXGR1 pathway using murine models and human tissue analysis.
Description
This project focuses on understanding how tuft cells remodel the airway barrier in ways that promote chronic inflammation, particularly in the context of airway type 2 inflammation (T2I). The research involves murine models and human tissue analysis to define the influence of tuft cells and cysteinyl leukotrienes (CysLTs) on wound repair and airway remodeling.