Award
National Institute of General Medical Sciences 5R01GM155651-02
Cytoskeletal compartmentalization of apoptotic signaling
Recipient
University of Connecticut Storrs
Award Amount
$322,000.00
Ceiling
$322,000.00
Awarded
July 16, 2025
Identifier
5R01GM155651-02
Research project funded by the National Institute of General Medical Sciences to study the interactions between cytoskeletal components and apoptotic signaling proteins, focusing on actin nucleation and caspase activity during apoptosis.
Description
This project investigates how the cytoskeleton, specifically actin nucleation factors, interacts with proteins that promote apoptosis. The research aims to define the molecular interactions between apoptosome proteins and the actin nucleation machinery, and to understand how caspases disrupt F-actin-rich territories during terminal apoptosis.