Award
NIH Reporter #1F32AI197474-01
Regulation of amidase activity during spore development
Recipient
TUFTS UNIVERSITY BOSTON
Award Amount
$75,880.00
Ceiling
$75,880.00
Awarded
March 30, 2026
Identifier
1F32AI197474-01
Award for research on the regulation of amidase activity during spore development in C. difficile to develop anti-spore germination therapies.
Description
This project aims to determine the molecular mechanisms underlying CwlD activation, localization, and coordination during spore development in C. difficile, with the goal of developing anti-spore germination therapies. The research involves genetic, biochemical, and structural approaches to understand enzyme regulation and inform therapeutic development to prevent disease transmission.