Award
National Institute of Allergy and Infectious Diseases 5R01AI173307-04
The novel role of HLA-E restricted CD8 regulatory T cells in kidney allograft rejection
Recipient
Brigham and Women's Hospital
Award Amount
$662,076.00
Ceiling
$662,076.00
Awarded
June 10, 2026
Identifier
5R01AI173307-04
This NIH grant funds research on HLA-E restricted CD8 regulatory T cells to understand and potentially control kidney transplant rejection by suppressing T follicular helper cells and antibody generation, aiming to improve long term allograft survival.
Description
Study the role of an antigen specific CD8 regulatory T cell subtype, restricted to HLA-E, in controlling kidney transplant rejection, particularly its role in suppressing T follicular helper cells and donor specific antibody generation in kidney transplantation.