Award
NIH Reporter #5R01HL174612-02
Impact of PIGA Loss on Hematopoietic Stem Cell Function
Recipient
University of Pennsylvania
Award Amount
$751,203.00
Ceiling
$751,203.00
Awarded
August 18, 2026
Identifier
5R01HL174612-02
NIH grant awarded to University of Pennsylvania to study the impact of PIGA gene loss on hematopoietic stem cell function, focusing on clonal expansion mechanisms in PNH, with a budget of $751,203 for FY 2026.
Description
This NIH grant focuses on studying the impact of PIGA gene loss on hematopoietic stem cell function, with a specific emphasis on understanding mechanisms underlying clonal expansion in PNH. The project involves multiple aims including functional analysis of PIGA loss, investigation of Notch signaling, and single-cell profiling techniques. The award is part of the NIH PA-20-185 funding opportunity, with a total budget of approximately $751,203 for FY 2026.