Award
Eunice Kennedy Shriver National Institute of Child Health and Human Development 5R21HD112763-02
In Utero Trophoblast Transgenesis
Recipient
Wright State University
Award Amount
$172,479.00
Ceiling
$172,479.00
Awarded
April 02, 2025
Identifier
5R21HD112763-02
This NIH-funded project seeks to establish a novel in utero trophoblast transgenesis method to facilitate placental research, with potential implications for understanding pregnancy disorders.
Description
The project aims to validate a novel in utero trophoblast transgenesis approach using lentiviral infection of blastocysts in utero. This method provides a rapid, trophoblast-specific, and highly efficient way to evaluate critical mediators of placental development and pregnancy-associated disorders. The approach eliminates the need for highly specialized staff, reduces technical complexity, and does not require embryo culture in vitro.