Award
National Institute of Diabetes and Digestive and Kidney Diseases 1K08DK146180-01
Role of Bile Acids in Time-Restricted Feeding
Recipient
University of California Los Angeles
Award Amount
$171,276.00
Ceiling
$171,276.00
Awarded
March 24, 2026
Identifier
1K08DK146180-01
Research project investigating the role of bile acids in the metabolic benefits of time-restricted feeding, aiming to develop novel therapies for metabolic diseases.
Description
Dr. Alvin Chan, a pediatric gastroenterologist and physician-scientist, aims to investigate the role of bile acids in mediating the metabolic benefits of time-restricted feeding (TRF). The project will explore how TRF influences bile acid synthesis, signaling, and lipid absorption, potentially leading to novel therapies for metabolic diseases. The research involves experiments in Western diet-fed mice, including disrupting bile acid synthesis via liver-specific AAV-CRISPR, and assessing bile acid signaling and intestinal adaptations.