National Institute of General Medical Sciences 5R35GM133501-07

Activity-based protein profiling of gut microbiota-associated bile acid metabolism

NIH funded research project at Cornell University to study gut microbiome enzymatic activity related to bile acid metabolism using chemical probes and imaging techniques.

Description

This project aims to develop chemical approaches to understand the metabolic activity of the gut microbiome, focusing on activity-based protein profiling to identify active bile acid metabolizing enzymes and bacterial proteins regulated by bile acids. The research will include developing chemical probes, characterizing bacterial proteins, and visualizing enzyme activity in health and disease.

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