Award
Yale University 1F31DK146643-01
Probing parathyroid organogenesis to instruct stem cell differentiation strategies
Recipient
Yale University
Award Amount
$53,114.00
Ceiling
$53,114.00
Awarded
April 28, 2026
Identifier
1F31DK146643-01
Award to Yale University for research on generating functional parathyroid-like cells from iPSCs to develop transplantable parathyroid tissue for hypoparathyroidism treatment.
Description
The project aims to generate functional parathyroid-like cells from human induced pluripotent stem cells (iPSCs) through directed differentiation. The work involves guiding iPSCs through stages of definitive endoderm, anterior foregut endoderm, and pharyngeal endoderm. The project will assess expression of parathyroid-specific markers and calcium-responsive PTH secretion. The project is enabled by Yale University's facilities and interdisciplinary supervision. The ultimate goal is to provide an autologous source of transplantable, functional parathyroid tissue to restore calcium homeostasis in individuals with hypoparathyroidism.