Award
National Institute on Aging 5R01AG081698-04
Levothyroxine Dosing in Older Individuals
Recipient
University of Pennsylvania, Philadelphia, PA
Award Amount
$546,805.00
Ceiling
$546,805.00
Awarded
April 17, 2026
Identifier
5R01AG081698-04
This award funds a randomized, double-blind clinical trial to determine the clinical consequences of different levothyroxine dosing strategies in older adults, potentially transforming hypothyroidism treatment for millions of older individuals.
Description
A clinical trial to evaluate different dosing strategies of levothyroxine in older adults, aiming to optimize treatment safety and efficacy. The study will compare two 6-month dosing strategies of levothyroxine in patients aged 65 years and older to assess effects on symptoms of hypothyroidism, mood, sleep, memory, executive function, weight, lipids, and bone turnover markers.