Award
National Institute of Allergy and Infectious Diseases 5R01AI126915-09
Immunological and Microbial Mechanisms in Food Allergy
Recipient
Boston Children's Hospital
Award Amount
$627,598.00
Ceiling
$627,598.00
Awarded
December 30, 2025
Identifier
5R01AI126915-09
Research project funded by NIAID to study immune and microbial mechanisms in food allergy, focusing on the role of RELMb and immune tolerance to develop new therapies.
Description
This project aims to understand how a gut protein called resistin like molecule beta (RELMb) disrupts immune tolerance to ingested foods, leading to food allergy. The study will explore immune regulatory checkpoints and mechanisms to reset immune responses to promote oral tolerance, potentially leading to novel therapies.