Award
National Eye Institute 5R01EY027406-08
The Mechanism of Sigma 1 Receptor Mediated Neuroprotection in Glaucoma
Recipient
Augusta University, Department of Ophthalmology
Award Amount
$421,655.00
Ceiling
$421,655.00
Awarded
May 13, 2026
Identifier
5R01EY027406-08
NIH grant awarded to Augusta University to study the role of sigma-1 receptor in neuroprotection for glaucoma by investigating astrocyte secretome effects on retinal ganglion cells.
Description
This project investigates how sigma-1 receptor (S1R) regulates protein secretion from optic nerve head astrocytes (ONHAs) to protect retinal ganglion cell (RGC) axons. The research aims to identify therapeutic targets within the astrocyte secretome to mitigate RGC death.