Award
National Cancer Institute PA-20-185
A novel role for EZH2 in PARP regulation and PARPi-resistance in prostate cancer
Recipient
Northwestern University
Award Amount
$1,701,594.00
Ceiling
$1,701,594.00
Awarded
June 30, 2026
Identifier
PA-20-185
NIH grant awarded to study EZH2's role in PARP regulation and resistance to PARP inhibitors in prostate cancer, aiming to develop new targeted inhibitors.
Description
The project investigates the role of EZH2 in prostate cancer, focusing on its methylation of PARP1 and implications for PARP inhibitor resistance. The project aims to develop new inhibitors targeting EZH2 and PARP1. The award is from the NIH, with a focus on cancer research. The project involves multiple investigators and is funded for nearly 3 years.