Award
NIH Reporter #1R21AG086883-01
Regulated gene circuits for Alzheimer's disease therapy
Recipient
Vanderbilt University, Nashville, TN, United States
Award Amount
$430,884.00
Ceiling
$430,884.00
Awarded
April 12, 2024
Identifier
1R21AG086883-01
The award funds a project to develop synthetic biology tools to engineer CNS cells to dynamically respond to Alzheimer's disease pathology, aiming to create new therapeutic approaches to combat neurodegeneration.
Description
This project proposes to develop synthetic biology tools to engineer astrocytes and microglia as programmable agents to respond to Alzheimer's disease pathology, specifically targeting amyloid-beta and hyperphosphorylated tau. The goal is to enable these cells to produce neuroprotective biologic drugs in response to disease signatures, thereby supporting neuronal health and counteracting neurodegeneration.