Award
Arkansas Department of Veterans Affairs 5I01BX003901-07
Antibodies against Oxidized Phospholipids and Osteoporosis
Recipient
CENTRAL ARKANSAS VETERANS HLTHCARE SYS
Awarded
December 11, 2025
Identifier
5I01BX003901-07
Research project focused on developing antibody-based therapies targeting oxidized phospholipids to treat osteoporosis and related diseases, involving preclinical and clinical studies.
Description
This project investigates the role of oxidized phospholipids containing phosphocholine (PC-OxPLs) in various diseases, including osteoporosis, cardiovascular diseases, and steatohepatitis. It explores the therapeutic potential of natural and monoclonal antibodies, particularly E06 IgM and IgG, in increasing bone mass and preventing disease progression.