Award
National Institute of Neurological Disorders and Stroke 1F31NS139494-01A1
Default Mode Network Inflammation as a Supraspinal Mechanism of Pain Chronification
Recipient
PENNSYLVANIA STATE UNIV HERSHEY MED CTR
Award Amount
$36,562.00
Ceiling
$36,562.00
Awarded
July 25, 2025
Identifier
1F31NS139494-01A1
NIH/NINDS awarded $36,562 to study Default Mode Network inflammation and its role in pain chronification using a rat model, focusing on cytokine expression and microglial silencing effects.
Description
The project involves examining the Default Mode Network (DMN) connectivity changes in a rat model of peripheral nerve injury to understand pain chronification. The study includes characterizing cytokine and chemokine expression in multiple DMN nodes. The project aims to test if microglial silencing can reverse changes in DMN connectivity and pain behaviors. The award is funded by the NIH/NINDS with a total cost of $36,562 for the fiscal year 2025.