Award
NIH Reporter #11348215
Structural and Functional Characterization of RhoGEF Regulation Using Nanodiscs to Assemble Membrane-associated Signaling Scaffolds
Recipient
National Institute of General Medical Sciences (NIGMS)
Award Amount
$388,705.00
Ceiling
$388,705.00
Awarded
June 08, 2026
Identifier
11348215
This NIH-funded project by NIGMS aims to study RhoGEF protein regulation at lipid membranes using advanced techniques to develop cancer therapeutics.
Description
The project focuses on the molecular understanding of RhoGEF proteins, particularly the P-Rex subfamily, and their regulation at lipid membranes. The research involves cryo-EM studies, nanodiscs, and rational design of therapeutic molecules. The project aims to develop therapeutics targeting RhoGEF proteins implicated in cancer.