Award
University of Pennsylvania 5R01HG012445-05
Mendelian inheritance of artificial chromosomes
Recipient
University of Pennsylvania
Award Amount
$1,169,628.00
Ceiling
$1,169,628.00
Awarded
July 31, 2025
Identifier
5R01HG012445-05
NIH awarded approximately $1.17 million to the University of Pennsylvania for a project to develop synthetic mammalian artificial chromosomes with faithful germline inheritance using mouse models.
Description
The project aims to construct synthetic mammalian artificial chromosomes with faithful inheritance through the germline, using mouse as a model. The project involves designing MAC vectors, assembling large synthetic DNA, and creating animals for in vivo testing. The project is funded by NIH, with a total award amount of approximately $1.17 million. The project duration is from July 1, 2025, to June 30, 2027.