Award
National Heart, Lung, and Blood Institute 5R01HL158667-05
Mechanistic Relationships Between Fibrosis, Fibrillation, and Stroke: Multi-Scale, Multi-Physics Simulations
Recipient
University of Washington
Award Amount
$581,972.00
Ceiling
$581,972.00
Awarded
March 27, 2026
Identifier
5R01HL158667-05
The project develops a computational framework to study how left atrial fibrosis contributes to thrombogenesis and stroke risk, validated through a clinical study, to improve stroke prevention strategies.
Description
This NIH grant project aims to use computer modeling and medical imaging to understand stroke risk by simulating structure, electrical activity, contraction, and blood flow in the heart, focusing on the mechanistic links between fibrosis, atrial fibrillation, and stroke.