Award
NIH Reporter #2R01DK050107-30
Transcriptional control of hemoglobin synthesis and erythrocyte development
Recipient
University of Wisconsin-Madison, Madison, WI, United States
Award Amount
$772,173.00
Ceiling
$772,173.00
Awarded
April 16, 2026
Identifier
2R01DK050107-30
The award supports research on the transcriptional control of hemoglobin synthesis and erythrocyte development, investigating how inflammation affects erythroid progenitors and small molecule homeostasis, with implications for anemia and blood disorders.
Description
This project aims to elucidate the molecular mechanisms regulating erythrocyte development, focusing on inflammation's impact on erythroid progenitors and the regulation of hemoglobin synthesis. It involves multi-omics approaches and gene editing strategies relevant to sickle cell disease and thalassemia therapies.