Award
National Institute on Aging 5R01AG075813-05
The interaction effects of genetic variants, age, diet, sex and mitochondrial copy number on Alzheimer's disease, aging-phenotypes and longevity
Recipient
University of Tennessee Health Science Center, Memphis, TN, United States
Award Amount
$484,593.00
Ceiling
$484,593.00
Awarded
December 15, 2025
Identifier
5R01AG075813-05
Research project funded by the National Institute on Aging to study how genetic variants, age, diet, sex, and mitochondrial DNA copy number interact to affect Alzheimer's disease, aging phenotypes, and longevity using mouse models, aiming to inform precision medicine.
Description
This project aims to provide quantitative, unbiased, and replicable data on genetic, molecular, and environmental processes influencing cognitive decline, Alzheimer's disease, and longevity, with the goal of enabling precision medicine approaches. It investigates gene-by-environment interactions linking mitochondrial DNA copy number to Alzheimer's disease and aging-relevant phenotypes using mouse models, analyzing relationships with age, sex, diet, and genetic factors.