Award
National Heart, Lung, and Blood Institute 5R00HL177822-02
Defining the Innate Immune Cell Profile of Factor VIII Immunity
Recipient
Stanford University
Award Amount
$393,856.00
Ceiling
$393,856.00
Awarded
April 02, 2026
Identifier
5R00HL177822-02
NIH grant awarded to Stanford University to study immune responses related to factor VIII inhibitors in hemophilia A, aiming to develop new immune tolerance therapies.
Description
This NIH grant project investigates the innate immune profile, including the cytokine microenvironment, of inhibitor development against coagulation protein factor VIII using murine models of hemophilia A, patient samples, and novel transcriptomic tools. The goal is to elucidate mechanistic drivers of factor VIII immunity and foster innovative therapies for immune tolerance induction.