Award
National Institute of Allergy and Infectious Diseases 1R01AI187292-01A1
Defining Protective IgGs to Food Allergy
Recipient
Massachusetts General Hospital, Boston, MA, United States
Award Amount
$806,466.00
Ceiling
$806,466.00
Awarded
July 29, 2025
Identifier
1R01AI187292-01A1
Research project to identify protective IgG antibody signatures in peanut allergy and establish biomarkers for oral immunotherapy outcomes.
Description
This project aims to define the characteristics of IgG antibodies that protect against peanut allergy, which is relevant to public health due to the burden of food allergies. The research will generate basic immunology knowledge about the roles of IgG and IgE in food allergy and establish biomarkers following oral immunotherapy (OIT). The study involves profiling peanut-specific IgG responses in adults undergoing OIT, with a focus on identifying signatures associated with successful outcomes such as tolerance or sustained unresponsiveness.